Biological Dose Optimization Using the Levenberg-Marquardt Method
نویسندگان
چکیده
The treatment planning software TRiP98 [1, 2, 3] is successfully used in the ion therapy project at GSI. A crucial part of the treatment planning is the particle number optimization in order to achieve a target dose distribution as close as possible to the prescribed biological dose distribution. The optimization task can be expressed mathematically by the minimization of a multidimensional objective function by means of the least squares method. In this contribution we examine the Levenberg-Marquardt method (LMM), used to handle the optimization problem.
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تاریخ انتشار 2009